Secretagogues: Amino Acids that stimulate the endocrine system to increase hormonal secretions. Directions on how to make your own custom nutritional stack.  You can design / make  a 1st thing in the morning stack, pre-workout stack, post-workout stack and pre-sleep stack.. each  customized  for time of day & situation.  By mixing your own stacks you can optimize for your metabolism or goals. If you have a damaged Anterior Pituitary or Hypothalamus gland Secretagogues will not work for you.  These glands must be intact for the Secretagogue supplementation to work. By combining specific amino acids and other synergistic nutrients we can trigger desired responses by specific glands.  The basis for increasing the Human Growth Hormone level is the use of HGH releasers or agonists. Secretagogues are substances that stimulate the endocrine system to increase growth hormone secretions. One would be hard pressed to find a 21st century exercise or nutrition publication that does not tout the benefits of amino acid supplementation. Amino Acid Nutritional Stacks based on published research. Amino Acid HGH Secretagogue products that are comparable to the recommendations cited in Dr. Klatz' 1998 research, published in his 1998 book, "Grow Young With HGH". A 300+ page book providing supporting lab work & extensive research procedural documentation. There are numerous books on the effectiveness of amino acid Secretagogues.  Dr. Klatz, Dr. DiPasquali, Sandy Shaw & Dirk Pearson all have books out with supporting lab work. There is a consensus that dietary control & proper exercise are important for success. 2005 Syracuse University: Dr. Jim Stoppani, Flex Magazine: A Research Project on men between 18 & 35 has published a report showing that that 6 grams to 9 grams of Arginine acts as a HGH Secretagogue.  A 9 gram L-Arginine serving increased serum HGH by over 60%,  from 4mcg/liter to 6.5 mcg/liter.

• At 40 HGH is about 75% that of a 25-30 year old ... production is 25% less & maybe you feel a little different.

• At 50 HGH is about 55% that of a 25-30 year old... the 45% decline combines with accumulated deficit & you feel it.

• At 60 HGH is about 40% that of a 25-30 year old... a 60% decline + the effects snow ball.

21st century medical studies from several American University Medical Schools, summarized & linked to below, document that hormone replacement therapy is a valid medical protocol..

New England Journal of Medicine. THE 1990 report: "Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occurs in old age. "(N Engl J Med 1990; 323:1-6.)

• Science Daily, December 22, 2006: A medical report from the University of Pittsburg Medical School, & supported by the National Institute of Aging, takes HRT's benefits to the cellular / DNA level.

• Report 1: The accumulation of genetic damage in our cells is a major contributor to how we age.

• Report 2: There is a direct relationship between DNA damage & aging.  Aging is driven by a build up of damaged DNA in cells.  These findings unify 2 of the theories on aging.

• Laura Niedernhofer, M.D., Ph.D., Professor of Molecular Genetics, U of Pittsburgh Medical School, reports, "..how we respond to cellular DNA damage is determined by the HGH & Insulin pathways."

• The rate of physical & mental decline we experience with aging is determined by cellular / DNA damage.  Cellular / DNA damage we all accumulate over our lifetimes, but our response to that damage / repair of that damage is unique & individual.

• The higher the somatotroph (growth hormone) axis level the better.

  • This medical school study on DNA damage demonstrates positive repair is directly proportional to somatotroph (growth hormone secretion regulator hormone GHRH) level.

• 2006: Dr. George R. Merriam, University of Washington: In older adults, increased human growth hormone has resulted in significant improvements in muscle mass & endurance.

• Mayo Clinic, "These results document that growth hormone can help healthy older adults who have low levels of growth hormone regain some of their youth and vitality."

• Colorado State University: "..frailty, muscle atrophy, relative obesity, increased frequency of fractures and disordered sleep. These clinical signs of aging are, without doubt, the manifestation of a very complex set of changes which involve, at least in part, the GH-axis (= growth hormone level)."

•  2007, Journal of Endocrinology. Growth hormone is critical to maintaining bone mass.

  • ".. GH is able to modulate bone remodeling by directly influencing osteoblast-osteoclast cross-talk."

• Edward M. Lichten, M.D.,P.C. "One of HGH’s most dramatic effects is on the connective tissue, muscle, and healing potential of the skeletal system." 

  • The positive effect HGH has on bone mass is documented by bone scan.

• Growth factors appear to maintain memory with aging.

• Many age related medical conditions are positively affected by Hormone Replacement Therapy, HRT.

• Human Growth Hormone injections in the days and weeks after a stroke could lead to greatly improved recovery rates.  ABC News

we have only 1 dietary rule: Eat nothing today that you will regret eating tomorrow.

• MIT study confirms melatonin's value as sleep aid

• True rest occurs in REM / Delta (DEEP) Sleep.  When was the last time you had a vivid dream? I love the REM dream state.

Many of the health issues, age related medical conditions, middle-aged persons begin to experience are directly related to diminished hormone production.

Long term medical research HAS BEEN COMPLETED regarding hormone replacement & antiaging.

1. January 24, 2008  The U.S. Food and Drug Administration has approved Cangene Corp's Accretropin Brand Somatropin recombinant human growth hormone injection for pharmaceutical dispensing.

2. January, 2008. Biopharmaceutical company Tercica, Inc. (TRCA) has begun Phase II clinical testing the combination of Genentech, Inc.'s (DNA) recombinant human growth hormone Nutropin AQ and Tercica's recombinant insulin-like growth factor-1 Increlex. Expected to be on the market in 2009.

3. January, 2008. Auxilium Pharmaceuticals (NASDAQ: AUXL) in conjunction with Bentley Pharmaceuticals (NYSE: BNT) has patented a new 1% testosterone gel Testim®..It is expected to market in 3rd quarter 2008.U.S. Patent No. 7,320,968 expires January 2025

4. December, 2007.  Israeli Biotech firm TEVA has purchased CoGenesys for $400m US.  CoGenesys reciently aquired a patent on a new production technique Albumin Fusion technology an advancement in recombinant DNA technology.    TEVA produces rhGH under the Trade Name Tev-Tropin.

5. July, 2007: US based US-based Dowpharma (Dow Chemical Pharmaceuticals) has licensed an Indian Pharmaceutical firm to produce rhGH using Pfenex Expression Technology.  Pfenex Expression Technology thus far has produced higher yields & lower cost than current (Somatrem's Inclusion Body Technology & Somatropin's Protein Secretion Technology). Dowpharma expects to be a major player in the global market with a production goal of 5% of the global rhGH from the 1 India plant market by 2011.

6. April, 2006:  The US FDA was ordered by a Federal judge to stop with holding approval for Sandoz's Omnitrope Somatropin.  The FDA granted approval on June1, over the objection of Pfizer's lobbyist greedily seeking protection from fair competition.  Omnitrope is bio-identical to Pfizer's Somatropin rhGH but is set to be priced 25% lower!  Sandoz was forced to wait over 3 years to market it's bio-identical rhGH because of the Pfizer lobbyist's 'scam' to avoid fair competition.

7. December 20, 2006:  Genentech, the worlds second largest biopharmaceutical / biotechnology company, acquires a once per week rhGH technology from Altus!

8. August, 2006 - A University of Pennsylvania School of Medicine research program involving the relationship between non-coding RNAs and the hGH gene is leading to an understanding how remote RNA effects the function or dysfunction of the hGH gene.

9. May, 2006: After 6 months on Pfizer's new oral medication to increase Human Growth Hormone, HGH, middle aged patients demonstrated significant improvement in a multitude of tasks.  Since 1998 The AntiAging & Longevity Project has offered oral HGH amino acid secretagogue info freely, similar to what Pfizer is patenting.

10. Pfizer has entered a rhGH capacity expansion phase investing us$500 million in a expanded facility, to meet requirements of global manufacturing of Genotropin (somatropin), a top-selling human growth hormone.

11. This report from Business Wire indicates rhGH is under study to be included in Medicare part D reimbursement.  Calls for Biogeneric Insulin and Human Growth Hormone are part of the 2007 Medicare Part D review. See: Content outline section.

12. LillyMedicareAnswers, an "Outside Part D" Medicare Part D Patient Assistance Program by the Health and Human Services Office of Inspector General (OIG). OIG approval of LillyMedicareAnswers paves the way for the full implementation of  Humatrope, rhGH, to low-income seniors who are experiencing gaps in coverage.

13. Wisconsin Medicaid has re-reviewed several brands of rhGH and will add them to the PDL effective for DOS on and after April 3, 2006.  Norditropin, Nutropin AQ, Saizen, Tev-Tropin.  Of that group Saizen would be our choice.

The VA is in dire need of R.N. Medical Case Managers .. for injured military: 1-800-949-0000