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over 100 Links on this page = 21st Century Bibliography.
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The AntiAging & Longevity Project was founded in 1998 by a baby boomer Registered Nurse (DOB: 1946) |
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over 100 Links on this page = 21st Century Bibliography.
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The AntiAging & Longevity Project was founded in 1998 by a baby boomer Registered Nurse (DOB: 1946) |
In August 1996 the US Food & Drug Administration first approves prescription injectable rhGH treatment for adults.
2007 FDA rhGH Report to Congress: why the FDA approves adult prescription recombinant human Growth Hormone (rhGH).
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Health and Quality of Life define Wealth. You're never to old to become Healthier & Wealthier.
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Adult rhGH auto-injection devices.
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The Endocrinology of Aging: Many age associated mental & medical conditions are based in declining endocrine function.
At 40 endogenous GH is about 75% that of a 25-30 year old ... production is 25% less & maybe you feel a little different.
At 50 endogenous GH is about 55% that of a 25-30 year old... the 45% decline combines with accumulated deficit & you feel it.
At 60 endogenous GH is about 40% that of a 25-30 year old... a 60% decline + the effects snow ball.
2008 marks 50 Years of Doctor Prescribed injectable hGH Therapy.
In 1958 Tufts University School of Medicine researcher Dr. Maurice Raben treated a 17 year old patient with Growth Hormone extracted from cadaver Anterior Pituitary glands.
Creutzfeldt-Jakob Disease (CJD) is the human form of spongiform encephalopathy, the bovine form of spongiform encephalopathy is commonly known as Mad Cow Disease. Both are transmitted through contaminated Central Nervous System material. From 1958 - 1985 Somatotropin was extracted from cadaver brains & was a source of contaminated CNS material.
1985: Bio-Tech giant Genentech patented 1st generation biosynthetic rhGH Somatrem, methionyl-growth hormone or met-GH. Biosynthetic Somatrem ended the potential of CJD, Crutchfield-Jacobs Disease. Somatrem met-GH is a 192 amino acid molecule.
The Anterior Pituitary secreted hGH molecule, endogenous Somatotropin, has191 amino acids in a specific organic structure. 191 Amino Acid Sequence designates the position each of the 191 amino acids holds in the human GH molecule's amino acid structure. (A change of even 1 amino acid alters the molecule's properties.)
1993-2008: Genentech's second generation biosynthetic rhGH, Somatropin, is rDNA derived & b
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Like Mr. Nietzsche reputedly stated . The doer alone learnth. We could be divided into 3 groups:
It's not the men in my life, it's the life in my men. ~ Mae West... or the life in my woman! ED |
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April 18, 2008. LA Chronicle: The hormone injections have proven to offer amazing benefits Dr Ronald Klatz of the American Academy of AntiAging Medicine, “Nearly 20,000 clinical studies conducted around the world document the broad benefits of pharmacological hGH therapy. " February, 2008: Dr. Andre Berger reports that in his LA Clinic, "... human Growth Hormone therapy (rhGH) for the treatment of adult growth hormone deficiencies has helped thousands of my patients, men and women, feel more energetic and more vibrant." & This second Mayo Clinic report provides a list of aging symptoms with the whys. April 22, 2008: NBC News: Mainstream Physicians Join Anti-Aging Movement. hGH may not improve a young athlete's performance, a young ballerina's bas or a young pianist's concerto. Will rhGH improve a 40+ year old player's fastball or homerun swing? |
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Feb 11, 2008 Roger Clemens Congressional Baseball Committee: Proper adult use of growth hormone is effective & safe
hGH increases energy levels and metabolic rate, boosts libido and improves mental well being. |
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"HGH" Sprays are stupid!
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Hormonal demise is often responsible for the physical & cognitive issues experienced with aging.
Natural Anterior Pituitary hGH is Somatotropin. Somatropin is rhGH. Both are 191 amino acid chain hormones.
'95-'08, 21st Century 2008: rhGH Somatropin is dispensed under assorted Trade Names. 3rd Generation rhGH, long lasting, is in Second Phase FDA Testing. |
Several rhGH Somatropin brands come pre-mixed in an easy to administer auto-injection device.
Omnitrope Pen® Injection Device video: Step by step video instructions for the Omnitrope Pen (Sandoz Somatropin)
Saizen Cool Click® Injection Device. (Merck-Serono Somatropin) |
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2006: Dr. Richard A. Rydze 1972: Olympian "Dickey" Rydze. Med Student "Dickie" Rydze was the Silver medallist in platform diving at the 1972 Munich Olympic Games (1972 Munich Olympics: Terrorist attack on Israeli athletes & Mark Spitz's 7 gold medals). Young med student Dickey Rydze was topped only by 3 time Olympic Platform Diving winner Italian Klaus Dibiasi. Professional Olympian Dibiasi won a total of 5 Olympic gold medals & barely topped young Dr. Rydze. |
A team doctor for the NFL's Pittsburgh Steelers, Dr. Richard A. Rydze, reports that he prescribes AMA & FDA approved rhGH & Testosterone HRT for older patients in his private practice.
Medical director for the charitable Little Sisters of the Poor Nursing Home Medical director of the Community College of Allegheny County Medical director of the FBI's Pittsburgh office Senior aviation medical examiner for the Federal Aviation Administration. |
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Benefits of Adult rhGH Therapy.
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April 18, 2008. LA Chronicle: The hormone injections have proven to offer amazing benefits Dr Ronald Klatz of the American Academy of AntiAging Medicine, “Nearly 20,000 clinical studies conducted around the world document the broad benefits of pharmacological hGH therapy. " February, 2008: Dr. Andre Berger reports that in his LA Clinic, "... human Growth Hormone therapy (rhGH) for the treatment of adult growth hormone deficiencies has helped thousands of my patients, men and women, feel more energetic and more vibrant." & This second Mayo Clinic report provides a list of aging symptoms with the whys.
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AntiAging Medicine is often referred to as Aging Management Medicine. A realistic goal of an AntiAging program is to delay the onset of & to slow the progression of Aging's Symptoms A Patient's Advocate Medical Provider / Doctor is necessary for optimized aging. The better the Doctor the better the examination room communication. 2 way communication. A good Doctor listens. Doctor shopping to achieve your personal goals is 100% acceptable.
HMO Doctors are often not dedicated to individualized medicine orpersonalized patient care. Demand personalized medical care!!! Choice of medical care provider should not be a random pick & certainly not a decision delegated to a HMO. |
Women's International Pharmacy can provide a list of competent doctors
by state.
Go to Women's International Pharmacy web site's "resources" page
Women's International dispenses
Bio-Identical 191 sequence
Saizen®
+ is an extremely efficient pharmacy
.. speak to a pharmacist at any time .. max 30 second wait.
"If I'd know I was going to live this long I'd taken better care of my self
" ~ Mickey Mantle (1931-1995)
Mayo Clinic Human Growth Hormone report demonstrates hGH's benefits:
Bolster the heart's ability to contract
Improve mood and motivation
Increase exercise capacity
Increase muscle mass
Increase bone density
Decrease body fat
Primary factors for an early demise:
tobacco
alcohol
obesity
high-blood pressure
high cholesterol
poor diet
lack of exercise
most are personally or medically controllable.
Most stupid choices are fairly obvious mistakes. Doh!
stop smokin', drink intelligently, exercise .. & use protection when you should
we have only 1 dietary rule: Eat nothing today that you will regret eating tomorrow.
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Tobacco kills the equivalent of 30 x 747 hijackings per day Cigarettes kill more than 3 9/11s per day!Erectile Dysfunction is 40% more likely among smokers. |
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June, 2008. Us News & World Report: Restful sleep is associated with healthy / successful aging.
University of Chicago researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45.
When was the last time YOU had a vivid dream? Dreaming, REM Sleep, is a good thing!
I'll let you be in my dream, if I can be in yours ~ Bob Dylan, circa 1963
Melatonin, a hormone secreted by the Pineal Gland, is extremely helpful in resolving age related sleep issues.
You have to stay in shape. My grandmother, she started walking five miles a day when she was 60. She's 97 today and we don't know where the hell she is. ~Ellen DeGeneres
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March 27, 2008: Researchers at UC Berkeley, Shanghai Institute & Columbia University have identified hGH & it's metabolites IGF-1 & IGF-2 as axon guidance molecules .. hGH, IGF-1 & IGF-2 actually facilitate the connectivity within the brain of individual neuron cells. Each brain neuron connects to 10,000 other neurons via the axons. hGH, IGF-1 & IGF-2 greatly facilitate this neuron > axon process.
This University report states hGH, IGF-1 & IGF-2 are absolutely required (absolute required is their phrase!) for new neuron formation and the required interconnectivity via the axons.
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Dr. Ronald Klatz' 1998 book Grow Young With HGH is the Amino Acid Secretagogue Bible. "HGH" Sprays are stupid! Spray "not-HGH" in nanograms(ng)=.000000001 gram(billionth!)="drops in an Olympic pool". No way, José! Amino Acid Secretagogue "Releasers" work. The Aminos must be present in grams not milligrams(>20 pills) + protocol adherence |
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Secretagogues: Amino Acids that stimulate the endocrine system to increase hormonal secretions. Directions on how to make your own custom nutritional stack. You can design / make a 1st thing in the morning stack, pre-workout stack, post-workout stack and pre-sleep stack.. each customized for time of day & situation. By mixing your own stacks you can optimize for your metabolism or goals.
2005 Syracuse University: Dr. Jim Stoppani, Flex Magazine: A Research Project on men between 18 & 35 has published a report showing that that 6 grams to 9 grams of Arginine acts as a HGH Secretagogue. A 9 gram L-Arginine serving increased serum HGH by over 60%, from 4mcg/liter to 6.5 mcg/liter. |
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Sylvester Stallone discusses using rhGH in preparation for his new Rambo
movie.
It's
impressive that 61 year old Sly Stallone is still authoritative as Green Beret
John Rambo.
"Everyone over 40 years old would be wise to investigate adult HRT because it improves the quality of your life." rhGH Advocate Sylvester Stallone in People Magazine. |
The University of California at San Francisco is naming it's new research center after rDNA derived Growth Hormone pioneer, William J. Rutter.
The William J. Rutter Center is situated on the UCSF campus across from Genentech Hall, the campus' other major research building.
Genentech Hall is part of a legal settlement.
UCSF won a court decision that rhGH was developed on the UCSF campus & that Genentech owed UCSF part of Genetech's $2,000,000,000. profit on rhGH.
Genentech Pharmaceuticals patented biosynthetic Insulin in 1982 as well as patenting biosynthetic hGH in 1985.
2008: Genentech Pharmaceutical (NYSE:DNA) remains the leader in HGH research holding the 1993 patent on Somatropin.
The University of California San Francisco Geriatric Resource Center. Information all baby boomers striving to be educated about their personal status should review.
check it out! .. must say it makes us feel good!
Without lifestyle changes 25% of all people born today will develop Type 2 Diabetes.
Exercise and weight control can reduce Type II Diabetes by 60%
Considering Testosterone Therapy?
A man 40 years old has less than 1/2 the testosterone a man of 25 has.
Low levels of testosterone increase death rate for men over 50. University of California, San Diego School of Medicine.
Testosterone replacement therapy may help elderly men with mild Alzheimer's disease. The University of California, Los Angeles team found that replacement hormone therapy significantly improved quality of life for Alzheimer's patients.
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.. even a few brisk walks per week can have a measurable effect Big belly / pot belly / pear shape in your 40s = 89% (!!) more Dementia in your 60s. Projections for 2050 Alzheimer's care far exceed the costs of the Iraq War. The only projected cure at this point involves stem cells. |
AntiAging Medicine as a specialty was founded in the early '90s .. as we baby boomers with 'incredibly high expectations' started hitting the 'middle age wall'.
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The issue of hormone replacement should be addressed by any comprehensive medical plan for baby boomers.
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21st century medical studies from several American University Medical Schools, summarized & linked to below, document that hormone replacement therapy is a valid medical protocol..
New England Journal of Medicine. THE 1990 report: "Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occurs in old age. "
(N Engl J Med 1990; 323:1-6.)Science Daily, December 22, 2006: A medical report from the University of Pittsburg Medical School, & supported by the National Institute of Aging, takes HRT's benefits to the cellular / DNA level.
Report 1: The accumulation of genetic damage in our cells is a major contributor to how we age.
Report 2: There is a direct relationship between DNA damage & aging. Aging is driven by a build up of damaged DNA in cells. These findings unify 2 of the theories on aging.
Laura Niedernhofer, M.D., Ph.D., Professor of Molecular Genetics, U of Pittsburgh Medical School, reports, "..how we respond to cellular DNA damage is determined by the HGH & Insulin pathways."
The rate of physical & mental decline we experience with aging is determined by cellular / DNA damage. Cellular / DNA damage we all accumulate over our lifetimes, but our response to that damage / repair of that damage is unique & individual.
The higher the somatotroph (growth hormone) axis level the better.
This medical school study on DNA damage demonstrates positive repair is directly proportional to somatotroph (growth hormone secretion regulator hormone GHRH) level.
Mayo Clinic, "These results document that growth hormone can help healthy older adults who have low levels of growth hormone regain some of their youth and vitality."
Colorado State University: "..frailty, muscle atrophy, relative obesity, increased frequency of fractures and disordered sleep. These clinical signs of aging are, without doubt, the manifestation of a very complex set of changes which involve, at least in part, the GH-axis (= growth hormone level)."
2007, Journal of Endocrinology. Growth hormone is critical to maintaining bone mass.
".. GH is able to modulate bone remodeling by directly influencing osteoblast-osteoclast cross-talk."
Edward M. Lichten, M.D.,P.C. "One of HGH’s most dramatic effects is on the connective tissue, muscle, and healing potential of the skeletal system."
The positive effect HGH has on bone mass is documented by bone scan.
Many age related medical conditions are positively affected by Hormone Replacement Therapy, HRT.
Current consensus is to withhold growth hormone from patients with cancer.
Journal of Endocrinology Nov, 2007: HGH is a beneficial treatment for cardiac disease via increased bioavailability of Nitric Oxide
Dr. William Regelson, University of Virginia School of Medicine reports that the hormone DHEA is "one of the best biochemical bio-markers for chronological age.
University of Chicago researchers found that the first stage of age-related deterioration of sleep quality in men occurs between the ages of 25 and 45.
When was the last time YOU had a vivid dream? Dreaming, REM Sleep, is a good thing!
I'll let you be in my dream, if I can be in yours ~ Bob Dylan, circa 1963
A low calorie diet is on your route to graceful aging
High cholesterol is linked to tied to brain impairment, memory loss, heart attacks and stroke.
The risk of heart disease could be cut by up to 55% if people became physically active by 40.
Begin exercise by your late 40s or early 50 to reduce the risk of dementia by about 50%
The first step is the hardest step!
Again, many of the most problematic symptoms of aging are effectively treated with Hormone Replacement Therapy.
LONG TERM RESEARCH demonstrates that estrogen replacement affords protection against Alzheimer's, the most benefit occurs if treatment is begun at or near the onset of menopause.
HGH and Testosterone can provide an improved quality of life. FACT!
0ver 50% of Testosterone is produced from DHEA.
There is strong relationship between sleep quality and physical and mental health. Proper rest is critical.
True rest occurs in REM / Delta (DEEP) Sleep. When was the last time you had a vivid dream? I love the REM dream state.
Many of the health issues, age related medical conditions, middle-aged persons begin to experience are directly related to diminished hormone production.
Long term medical research HAS BEEN COMPLETED regarding hormone replacement & antiaging.
July 29, 2003. Human Growth Hormone Gets New FDA Approved Use
The Food and Drug Administration has OK'd the use of growth hormone for children who are healthy but abnormally short and who hope to gain 1 to 3 inches of height.* ( *Our focus is for adult benefit only.) News article link.
We get many calls from adults wanting to gain height. After the growth plates on long bones is mature the height growth process has pretty much complete.
US Government FDA site: FDA Approves Humatrope ( E. Lily's brand name rhGH ) for Short Stature
Previously HGH has been approved to treat both adults & children for low HGH production by the Anterior Pituitary.
Now HGH is US FDA approved to treat 'shortness' determined to be unrelated to endocrine function.
Persons under the care of a Physician, on complex medical plans or taking multiple medications should always consult with their Physician before any dietary or nutritional supplementation changes are made. Current cancer patients, cancer patients in remission and previous cancer patients should consult with their Physician before considering any new exercise or nutrition program.
A medical check up is advised before beginning any nutritional, dietary or exercise program.
Realistic assessment of your current physical condition, to include genetics as well as wear & tear.
Directions on how to make your own custom nutritional stack.
High protein diets result in the release of a hormone, PYY, that curbs hunger in both obese and normal weight people. PYY levels are lowest amongst obese people.
In the 'old days' (60s, 70s & 80s) HGH was obtained from the pituitary gland of cadavers & there were possible negative effects & complication
Modern rhGH (recombinant HGH ) is a very safe prescription medication, especially when proper labs are utilized to monitor hormone levels to ensure proper dosage.. Based on proper lab work, primarily IGF-1, prescription HGH is an appropriate medical treatment.
